Publications

Scientific, Technical, and Science Policy Articles in Peer-Reviewed Journals

Bogen KT. Inflammation as a cancer co-initiator: New mechanistic model predicts low/negligible risk at noninflammatory carcinogen doses. Dose-Response 2019; 17(2):1559325819847834. doi: 10.1177/1559325819847834.

Bogen KT. Biphasic hCAR inhibition-activation by two aminoazo liver carcinogens. Nucl Receptor Res 2018; 5:101321. doi: 10.11131/2018/101321.

Bogen KT, Sheehan PJ, Valdez-Florez C, Li AA. Reevaluation of historical exposures to ethylene oxide among U.S. sterilization workers in the national institute of occupational safety and health (NIOSH) study cohort. Int J Envir Res Public Health 2019; 16:1738. doi: 10.3390/ijerph16101738.

Bogen KT. Inflammation as a cancer co-initiator: New mechanistic model predicts low/negligible risk at noninflammatory carcinogen doses. Dose-Response 2019; 17(2):1-12. doi: 10.1177/1559325819847834.

Bogen KT. Biphasic hCAR inhibition-activation by two aminoazo liver carcinogens. Nucl Receptor Res 2018; 5:101321. doi: 10.11131/2018/101321.

Sheehan P, Singhal A, Bogen KT, MacIntosh D, Kalmes RM, McCarthy J. Potential exposure and cancer risk from formaldehyde emissions from installed Chinese manufactured laminate flooring. Risk Anal 2018 (in press; e-published 15 Nov 2017). doi: 10.1111/risa.12926.

Bogen KT, Garry MR. Risks of allergic contact dermatitis elicited by nickel, chromium, and organic sensitizers: Quantitative models based on clinical patch test data. Risk Anal 2018 (in press; e-published 11 Oct 2017). doi: 10.1111/risa.12902.

Kerger BD, Bogen KT, Loccisano AE, Lamb JC. Proposed reference dose for toxaphene carcinogenicity based on constitutive androstanol receptor-mediated mode of action. Human Ecol Risk Assess 2018 (in press). doi: 10.1080/10807039.2017.1408397.

Kerger BD, Bogen KT, Loccisano AE, Lamb JC. Liver tumor potency indicators for technical toxaphene and congeners simulating weathered toxaphene. Human Ecol Risk Assess 2018; 24(3):830–846. doi: 10.1080/10807039.2017.1401450.

Bogen KT. Low-dose dose-response for in vitro Nrf2-ARE activation in human HepG2 cells. Dose-Response 2017; April-June:1–9. doi: 10.1177/1559325817699696.

Bogen KT. Linear-no-threshold default assumptions are unwarranted for cytotoxic endpoints independently triggered by ultrasensitive molecular switches. Risk Anal 2017; 37(10):1808–1816. doi: 10.1111/risa.12813.

Bogen KT, Arnold LL, Chowdhury A, Pennington KL, Cohen SM. Low-dose dose-response for reduced cell viability after exposure of human keratinocyte (HEK001) cells to arsenite. Toxicol Reports 2017; 4:32–38. doi: 10.1016/j.toxrep.2016.12.003.

Bogen KT. A new theory of chemically induced tumorigenesis: Key molecular events and dose–response implications. Adv Molec Toxicol 2017a; 10:1–53. doi: 10.1016/B978-0-12-804700-2.00001-5.

Bogen KT, Singhal A. Malathion dermal permeability in relation to dermal load: Assessment by physiologically based pharmacokinetic modeling of in vivo human data. J Environ Sci Health, Part B 2016; 52(2):138­–146. doi: 10.1080/03601234.2016.1248150.

Bogen KT. Linear-no-threshold default assumptions for noncancer and nongenotoxic-cancer risks: A mathematical and biological critique. Risk Anal 2016; 36(3):589–604. Open access: http://onlinelibrary.wiley.com/doi/10.1111/risa.12460/epdf [Society for Risk Analysis Best Paper of the Year Award (2016)]

Bogen KT, Heilman JM. Reassessment of MTBE cancer potency considering modes of action for MTBE and its metabolites. Crit Rev Toxicol 2015; 45 Suppl 1:1­–56. doi: 10.3109/10408444.2015.1052367.

Bogen KT. Stem cell division, mutations, and cancer risk. Science 2015; 26 Jan [online comment]. http://comments.sciencemag.org/content/10.1126/science.1260825 

Bogen KT. Unveiling variability and uncertainty for better science and decisions on cancer risks from environmental chemicals. Risk Anal 2014; 34(10):1795–1806. doi: 10.1111/risa.12290.

Bogen KT. Does EPA underestimate cancer risks by ignoring susceptibility differences? Risk Anal 2014; 34(10):1780–1784. doi: 10.1111/risa.12171.

Sheehan PS, Brorby GP, Berman DW, Bogen KT. Protecting good science. Ann Occup Hyg 2014; 58(2):267–268. doi: 10.1093/annhyg/met079.

Bogen KT. Mechanistic models fit to ED001 data on >40,000 trout exposed to dibenzo[a,l]pyrene indicate mutations do not drive increased tumor risk. Dose Response 2014; 12(3):386–403. doi: 10.2203/dose-response.13-019.Bogen. eCollection 2014.

Bogen KT, Sheehan PS. Dermal versus total uptake of benzene from mineral spirits solvent during parts washing. Risk Anal 2014; 34(7):1336–1358. doi: 10.1111/risa.12166.

Bogen KT. Efficient tumorigenesis by mutation-induced failure to terminate microRNA-mediated adaptive hyperplasia. Medical Hypotheses 2013; 80(1):83–93. doi: 10.1016/j.mehy.2012.10.017.

Bogen KT. Dermal uptake of 18 dilute aqueous chemicals: In vivo disappearance-method measures greatly exceed in vitro-based predictions. Risk Anal 2013; 33(7):1334–1352. doi: 10.1111/j.1539-6924.2012.01901.x.

Brorby GP, Sheehan PJ, Berman DW, Bogen KT, Holm SE. Exposures from chrysotile-containing joint compound: Evaluation of new model relating respirable dust to fiber concentrations. Risk Anal 2013; 33(1):161–176.

Berman DW, Brorby GP, Sheehan PJ, Bogen KT, Holm SE. More on the dynamics of dust generation: the effects of mixing and sanding chrysotile, calcium carbonate, and other components on the characteristics of joint-compound dusts. Ann Occup Hyg 2012; 56(7):852–867.

Bogen KT, Reiss R. Generalized Haber's law for exponential concentration decline, with application to riparian-aquatic pesticide ecotoxicity. Risk Anal 2012; 32(2):250–258.

Sheehan PJ, Brorby GP, Berman DW, Bogen KT, Holm SE. Chamber for testing asbestos-containing products: validation and testing of re-created chrysotile-containing joint compound. Ann Occup Hyg 2011; 55(7):797–809.

Bogen KT, Brorby G, Berman DW, Sheehan P, Floyd M. Measuring mixed cellulose ester (MCE) filter mass under variable humidity conditions. Ann Occup Hyg 2011; 55(5):485–494.

Brorby GP, Sheehan P, Berman DW, Bogen KT, Holm SE. Potential artifacts associated with historical preparation of joint compound samples and reported airborne asbestos concentrations. J Occup Environ Hygiene 2011; 8(5):271–278.

Bogen KT. Generic Hockey-Stick model for estimating benchmark dose and potency: performance relative to BMDS and application to anthraquinone. Dose-Response 2011; 9(2):182–208.

Sheehan P, Bogen KT, Hicks J, Goswami E, Brorby G, Lau EC, Ott B. Benzene inhalation by parts washers: new estimates based on measures of occupational exposure to solvent coaromatics. Risk Anal 2010; 30(8):1249–1267.

Bogen KT, Goswami E. Screening-Level Hazard Assessment for Six Phthalates Under A.B. 1108 and Proposition 65 (Rev. 1). Technical Report prepared by Exponent, Inc., for the Environment Section, Office of the Attorney General, California Department of Justice (CalDOJ), May 2009 (made public by CalDOJ, August 2009). Exponent Doc. no. 0800736.000 0601 0509 KB01. Exponent, Inc., Oakland, CA, 97 pp.

Bogen KT, Cullen AC, Frey HC, Price PS. Probabilistic exposure analysis for chemical risk characterization. Toxicol Sci 2009; 109(1):4–17.

Bogen KT. An adjustment factor for mode of action uncertainty with dual-mode carcinogens:  The case of naphthalene-induced nasal tumors in rats. Risk Anal 2008; 28(4):1033–1051. doi: 10.1111/j.1539-6924.2008.01066.x. [Society for Toxicology, Risk Analysis Specialty Section, Top 10 Publication Award (2008)]

Louis ED, Keating GA, Bogen KT, Rios E, Pellegrino KM, Factor-Litvak P. Dietary epidemiology of essential tremor: Meat consumption and meat cooking practices.  Neuroepidemiol 2008; 30(3):161–166.

Bogen KT, Benson JM, Yost GS, Morris JB, Dahl AR, Clewell HJ, Krishnan K, Omiecinski CJ.  Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action.  Regul Toxicol Pharmacol 2008; 51(2 Suppl 1):S27–S36.

Griego FY, Bogen KT, Price PS, Weed DL. Exposure, epidemiology and human cancer incidence of naphthalene.  Regul Toxicol Pharmacol 2008; 51(2 Suppl 1):S22–S26.

Bogen KT, Gouveia FJ.  Impact of spatiotemporal fluctuations in airborne chemical concentration on toxic hazard assessment. J Hazard Mater A 2008; 152(1):228–240.

Robison WL, Hamilton TF, Bogen KT, Conrado CL, Kehl SR.  137Cs inter-plant concentration ratios provide a predictive tool for coral atolls with distinct benefits over transfer factors.  J Environ Radioact 2008; 99(1):181–189.

Bogen KT, Jones ED, Fischer LE.  Hurricane destructive power predictions based on historical storm and sea surface temperature data. Risk Anal 2007; 27(6):1497–1517.

Bogen KT, Keating II GA, Chan JM, Paine LJ, Simms EL, Nelson DO, Holly EA.  Highly elevated PSA and dietary PhIP intake in a prospective clinic-based study among African Americans.  Prostate Cancer Prostatic Dis 2007; 10(3):261–269.

Keating GA, Bogen K, Chan J.  Development of a meat frequency questionnaire for use in diet and cancer studies.  J Am Dietetic Assoc 2007; 107(8):1356–1362.

Louis ED, Zheng W, Jiang W, Bogen KT, Keating GA.  Quantification of the neurotoxic β‑carboline harmane in barbecued/grilled meat samples and correlation with level of doneness.  J Toxicol Environ Health A 2007; 70(12):1014–1019.

Bogen KT.  Comment on “Steady state solutions to PBPK models and their applications to risk assessment I:  Route to route extrapolation of volatile chemicals.”  Risk Anal 2006; 26(6):1415.

Bogen KT, Jones ED.  Risks of mortality and morbidity from worldwide terrorism: 1968-2004.  Risk Anal 2006; 26(1):45-59.  [Society for Risk Analysis, Best Paper Award, Decision Science (2006)]

Bogen KT.  Risk analysis for environmental health triage.  Risk Anal 2005; 25(5):1085-1095.

Keating GA, Bogen KT.  Estimates of heterocyclic amine intake in the U.S. population.  J Chromatogr B 2004; 802:127-133.

Bogen KT, Marchetti A, Brown TA.  Use of a correlated compound-binomial model to assess absence of non-counting noise in Pu-isotope ratios measured by AMS at LLNL.  Nucl Instr Meth Phys Res B 2004; 223:209-215.

Enns L, Bogen KT, Wizniak J, Murtha AD, Weinfeld M.  Low dose radiation hypersensitivity is associated with p53-dependent apoptosis.  Molec Cancer Res 2004; 2:557-566.

Raber MS, Carlsen TM, Folks KJ, Kirvel RD, Daniels JI, Bogen KT.  How clean is clean enough?  Recent developments in response to threats posed by chemical and biological warfare agents.  Int J Health Res 2004; 14:31-41.

Robison WL, Conrado CL, Bogen KT, Stoker AC.  The effective and environmental half-life of 137Cs at coral islands at the former U.S. nuclear test site.  J Environ Radioact 2003; 69:207-223.

Bogen KT, Cullen J.  Residential radon in U.S. counties vs. lung cancer in women who predominantly never smoked.  Environ Geochem Health 2002; 24:229-247.

Bogen KT, Witschi HP.  Lung tumors in A/J mice exposed to environmental tobacco smoke: estimated potency and implied human risk.  Carcinogenesis 2002; 23:511-519.

Bogen KT.  Biologically based prediction of empirical nonlinearity in lung cancer risk vs. residential/occupational radon exposure.  Hum Ecol Risk Assess 2001; 7:811-827.

Bogen KT, Keating GA.  U.S. dietary exposures to heterocyclic amines.  J Expos Anal Environ Epidemiol 2001; 11:155-168.

Cullen J, Bogen KT.  Historical residential coal use and female lung cancer mortality.  Hum Ecol Risk Assess 2001; 7:369-385.

Keating GA, Bogen KT.  Methods to estimate heterocyclic amine concentrations in cooked meats in the U.S. diet.  Food Chem Toxicol 2001; 39:29-43.

Bogen KT, Enns L, Hall LC, Keating GA, Weinfeld M, Murphy G, Wu RW, and Panteleakos FN.  Gel microdrop flow cytometry assay for low-dose studies of chemical and radiation cytotoxicity.  Toxicol 2001; 160:5-10.

Daniels JI, Bogen KT, Hall LC.  Analysis of uncertainty and variability in exposure to characterize risk:  Case study involving trichloroethylene groundwater contamination at Beale Air Force Base in California.  Water Air Soil Pollut 2000; 123:273-298.

Keating GA, Sinha R, Layton D, Salmon CP, Knize MG, Bogen KT, Lynch CF, Alavanja M.  Comparison of heterocyclic amine levels in home-cooked meats with exposure indicators.  Cancer Causes Control 2000; 11:731-739.

Bogen KT.  Comments on papers by Andersen and Conolly and by Downs and Franowski.  Hum Exper Toxicol 1998; 17:711-712.

Bogen KT.  Mechanistic model predicts a U-shaped relation of radon exposure to lung cancer risk reflected in combined occupational and U.S. residential data.  Hum Exper Toxicol 1998; 17:691-696.

Bogen KT.  Response to reviewer comments.  Hum Exper Toxicol 1998; 17:716-718.

Bogen KT, Layton DW.  Risk management for plausibly hormetic environmental carcinogens: the case of radon.  Hum Exper Toxicol 1998; 17:463-467.

Bogen KT, Keating GA, Meissner S, Vogel JS.  Initial uptake kinetics in human skin exposed to dilute aqueous trichloroethylene in vitro.  J Expos Anal Environ Epidemiol 1998; 8:253-271.

Bogen KT.  Do U.S. county data disprove linear no-threshold predictions of lung cancer risk for residential radon?—A preliminary assessment of biological plausibility.  Hum Ecol Risk Assess 1997; 3:157-186.

Bogen KT, Swirsky Gold L.  Trichloroethylene cancer risk: simplified calculation of PBPK-based MCLs for cytotoxic endpoints.  Regul Toxicol Pharmacol 1997; 25:26-42.

Robison WL, Bogen KT, Conrado CL.  An updated dose assessment for a U.S. nuclear test site—Bikini Atoll.  Health Phys 1997; 73:100-114.

Bogen KT, Conrado CL, Robison WL.  Uncertainty and variability in updated estimates of potential dose and risk at a U.S. nuclear test site—Bikini Atoll.  Health Phys 1997; 73:115-126.

Bogen KT.  Improved prediction of carcinogenic from mutagenic potencies for chemicals positive in rodents and the Ames test.  Molec Environ Mutagen 1995; 25(1):37-49. doi: 10.1002/em.2850250107.

Bogen KT.  Methods to approximate joint uncertainty and variability in risk.  Risk Anal 1995; 15(3):411-419.

Layton DW, Bogen KT, Knize MG, Hatch FT, Johnson VM, Felton J.  Cancer risk assessment of heterocyclic amines in cooked foods:  An analysis and implications for research.  Carcinogenesis 1995; 16:39-52.

Bogen KT.  Applicability of alternative models of variance in replicate Ames-revertants measured for 121 mutagenic rodent carcinogens.  Mutat Res 1994; 322:265-273.

Bogen KT.  Cancer potencies of heterocyclic amines found in cooked foods.  Food Chem Toxicol 1994; 32:505-515.

Bogen KT.  Models based on steady-state in vitro dermal permeability data underestimate short-term in vivo exposures to organic chemicals in water.  J Expos Anal Environ Epidemiol 1994; 4:457-476.

Bogen KT.  A note on compounded conservatism.  Risk Anal 1994; 14(4):379-381.

Hamilton LD, Holtxman S, Meinhold AF, Morris SC, Pardi R, Rowe MD, Sun C, Anspaugh LR, Bogen KT, Layton DW, McKone TE, Straume T, Andricevic R, Jacobson RL.  Pilot study risk assessment for selected problems at three U.S. Department of Energy facilities.  Environ Int 1994; 20:585-604.

Bogen KT.  An intermediate-precision approximation of the inverse cumulative normal distribution.  Commun Statist Simulat 1993; 22:797-801.

Bogen KT.  Reassessment of human peripheral T-lymphocyte lifespan deduced from cytogenetic and cytotoxic effects of radiation.  Int J Radiat Biol 1993; 64(2):195–204.

McKone TE, Bogen KT.  Uncertainties in health-risk assessment:  An integrated case study based on tetrachloroethylene in California groundwater.  Regul Toxicol Pharmacol 1992; 15(1):86-103.

Bogen KT, Colston BW, Machicao LK.  Dermal absorption of dilute aqueous chloroform, trichloroethylene and tetrachloroethylene in hairless guinea pigs.  Fund Appl Toxicol 1992; 18(1):30-39.

McKone TE, Bogen KT.  Predicting the uncertainties in risk assessment.  Environ Sci Technol 1991; 25(10):1674-1681.

Bogen KT.  CKM carcinogenesis models:  Response.  J Natl Cancer Inst 1990; 82(21):1723-1724.

Bogen KT.  Of apples, alcohol, and unacceptable risk [guest editorial].  Risk Anal 1990; 10(2):199-200.

Bogen KT.  Risk extrapolation for chlorinated methanes as promoters vs. initiators of multistage carcinogenesis.  Fund Appl Toxicol 1990; 15(3):536-557.

Bogen KT.  Cell proliferation kinetics and multistage cancer risk models.  J Natl Cancer Inst 1989; 81(4):267-277.

Bogen KT.  Letter to the editor.  J Natl Cancer Inst 1989; 82:320.

Bogen KT, Hall LC.  Pharmacokinetics for regulatory risk analysis: The case of 1,1,1-trichloroethane (methyl chloroform).  Regul Toxicol Pharmacol 1989; 10(1):26-50.

Lichtenberg E, Zilberman D, Bogen K.  Regulating environmental health risks under uncertainty:  Groundwater contamination in California.  J Environ Econ Management 1989; 17(1):22-34.

Bogen KT.  Pharmacokinetics for regulatory risk analysis: The case of trichloroethylene.  Regul Toxicol Pharmacol 1988; 8(4):447-466.

Bogen KT, McKone TE.  Linking indoor air and pharmacokinetic models to assess tetrachloroethylene risk.  Risk Anal 1988; 8(4):509-520.

Bogen KT, Spear RC.  Integrating uncertainty and inter-individual variability in environmental risk assessment.  Risk Anal 1987; 7(4):427-436.

Zweig G, Gao R, Witt JM, Poppendorf W, Bogen KT.  Dermal exposure to carbaryl by strawberry harvesters.  J Agric Food Chem 1984; 32(6):1232-1236.

Bogen KT.  Quantitative risk-benefit analysis in regulatory decision-making: A fundamental problem and an alternative proposal.  J Health Politics Policy Law 1983; 8(1):120-143.

Bogen KT.  Coordination of regulatory risk analysis: Current framework and legislative proposals.  Environ Econ J 1982; 1:53-84.

Bogen KT, Carr GM. 1981. Agent Orange: Veteran’s complaints concerning exposure to herbicides in South Vietnam. Issue Brief No. IB 80040, updated May 12, 1981.  U.S. Library of Congress, Congressional Research Service, Science Policy Research Division, Washington, DC.

Bogen KT.  Public policy and technological risk.  IDEA:  J Law Technol 1980; 21:37-74.

Bogen KT.  Managing technical dissent in private industry.  Indust Labor Relations Forum 1979; 13:3-32.


Books and Monographs

Bogen KT.  Uncertainty in Environmental Health Risk Assessment.  Garland, New York, 1990.

Bogen KT.  Uncertainty in environmental health risk assessment:  A framework for analysis and an application to a chronic exposure situation involving a chemical carcinogen.  Doctoral Dissertation, University of California Berkeley, School of Public Health, Berkeley, CA, 1986.

Book Chapters

Bogen KT, Fischer LE, Jones ED. 2011. Hurricane intensity, sea surface temperature, and stochastic variation.  In: Lupo A, ed. Recent Hurricane Research - Climate, Dynamics, and Societal Impacts.  ISBN: 978-953-307-238-8.  InTech, Rijeka, Croatia, pp. 103-118. Available from: http://www.intechopen.com/articles/show/title/hurricane-intensity-sea-surface-temperature-and-stochastic-variation.

Bogen KT, Homann SG, Gouveia FJ, Neher LA.  2009. A prototype near-field GIS model to characterize acute risks of sequestered CO2 release through orphan wells.  In:  Carbon Dioxide Sequestration in Geological Media—State of the Science.  Grobe M, Pashin J, Dodge R (eds), Am Assoc Petroleum Geologists (AAPG) Studies in Geology 59, pp. 587–593.

Keating GA, Bogen KT, Vogel JS.  Measurement of short-term dermal uptake in vitro using accelerator mass spectrometry.  pp. 475-486.  In:  Percutaneous Absorption:  Drugs, Cosmetics, Mechanisms, Methodology, Third Edition.  R.L. Bronaugh and H.I. Maiback (eds), Marcel Dekker, Inc., New York (Drugs Pharmaceutical Sci 97), 1999.

Bogen KT, Keating GA, Vogel JS.  Chloroform and trichloroethylene uptake from water into human skin in vitro:  Kinetics and risk assessment.  pp. 195-198.  In:  Prediction of Percutaneous Penetration, Volume 4b.  V.J. Brain, V.J. James, K.A. Walters (eds), STS Publishing Ltd., Cardiff, UK, 1996.

Bogen KT, Colston BW, Machicao LK.  Percutaneous absorption of dilute aqueous chlorinated organic solvents in the hairless guinea pig.  pp. 321-345.  In:  Drinking Water Contamination and Health.  R. Wang (ed), Marcel Dekker, Inc., New York, NY, 1994.

Daniels JI, McKone TE, Hall LC, Layton DW, Bogen KT.  Remedial investigation of a Superfund site.  pp. 67-82.  In:  Effective and Safe Waste Management:  Interfacing Sciences and Engineering with Monitoring and Risk Analysis.  R.L. Jolley, R.G. Wang (eds), Lewis Publishers, Boca Raton, FL, 1993.

Bogen KT.  Cancer-risk prediction for carbon tetrachloride using pharmacokinetic and cell-kinetic multistage models.  pp. 445-470.  In:  Risk Analysis:  Prospects and Opportunities.  Plenum Press, New York, NY, 1991.

Bogen KT, McKone TE.  Tetrachloroethylene metabolism resulting from domestic respiratory exposure:  Pharmacokinetic considerations relevant to risk assessment.  pp. 593-608.  In:  Risk Assessment in Setting National Priorities.  J.J. Bonin and D.E. Stevenson (eds), Plenum, New York, NY, 1989.

Zweig G, Gao R, Witt JM, Poppendorf W, Bogen KT.  Exposure of strawberry harvesters to carbaryl.  pp. 123-138.  In:  Dermal Exposure Related to Pesticide Use:  Discussion of Risk Assessment.  N.N. Ragsdale (ed), American Chemical Society, Washington, DC, 1985.

 

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