Areas of Practice
Applied toxicology & Chemical Toxicity Modeling
Applied toxicology services include: Dose-response analysis and characterization for cancer and non-cancer endpoints (e.g., using U.S. EPA Benchmark Dose or other appropriate software); Carcinogen mode of action (MOA) analysis and assessment; California Proposition 65 compliance assessment and compliance strategy development; Toxicity data interpretation; Mechanistic toxicity data analysis and modeling under static, dynamic, single-route, or multi-route exposure conditions; Dynamic toxic load models of toxic response likelihood (i.e., using the generalized Haber's law); Inter- and intra-species toxicity extrapolation.
Environmental, Occupational, & consumer product health Risk Assessment
Applied toxicology, chemical toxicity modeling, exposure assessment, and PK/PBPK/PBPD modeling can be combined to characterize and assess human health risks posed by chemical exposures in environmental, occupational, and consumer product contexts. Risk assessment services are typically chemical-specific and provided in relation to requirements for compliance with applicable federal, state, European, or other international standards. Risk characterization can involve joint analysis of applicable uncertainty and inter-individual variability, e.g., using methods Dr. Bogen developed.
Exposure assessment
Exposure assessment services include: Static, dynamic, single-route, or multi-route (e.g., dermal, inhalation, oral, dietary ingestion, hand-to-mouth ingestion, injection, or mixed) exposure modeling; Dose reconstruction based on assumptions supported by published data or on field measurements supplied, or developed by collaborative experimental design; Analysis of uncertainty and inter-individual variability in predicted exposures; Prediction and correction of chemical threat zone underestimation by atmospheric dispersion models that ignore levels of spatio-temporal variation in chemical concentrations typically encountered in urban/outdoor areas.
ionizing radiation exposure & cancer risk assessment
Expert services include analysis of environmental exposures to ionizing radiation and radionuclides, and quantitative assessment of associated cancer risks using a variety of established (e.g., U.S. EPA, NRC BEIR Committee, NCRP, U.S. DOE) radiation risk models, based on measures of radiation/radionuclide exposure either supplied by the client or subcontracted.
Expert Reports, Deposition, Testimony
These services are available as needed (see Services – Expert Designations).
biokinetic and pharmacokinetic modeling
Biokinetic and pharmacokinetic (PK) models describe and predict absorption, distribution, metabolism, and excretion (ADME) of elements or chemicals from the body under experimental, environmental, or clinical exposure conditions. Pharmacodynamic (PD) models use PK methods also to model toxic response kinetics. Physiologically based PK (PBPK) and physiologically based PD (PBPD) models use biologically realistic compartments and distribution mechanisms.
Mathematical modeling, statistical/biostatistical data analysis, database design & analysis, Experimental & Epidemiological Study Design
Mathematical modeling and data analysis services and associated reports can be prepared to address a broad range of scientific, technical, and other types of problems. Dr. Bogen has 30+ years of programming experience using the powerful and versatile Mathematica® software platform and related applications for data analysis, data visualization, mathematical modeling, probability modeling, model fitting, and uncertainty/variability characterization. Scientific study design and evaluation services take advantage of Dr. Bogen's 20+ years of experience designing and directing laboratory experiments and 7 years of experience designing and directing two federally funded epidemiology studies performed in collaboration with a California medical clinic.
Professional Ethics
All services are provided in adherence to the Code of Ethics of the Society of Toxicology. Any associated, client-authorized manuscripts prepared for journal submission will adhere to recommendations by the International Committee of Medical Journal Editors (ICMJE) for the conduct, reporting, editing, and publication of scholarly work in medical journals. Any collaborative project involving experimental animals must be pre-approved by an appropriate institutional Animal Care and Use Committee. Any collaborative experimental project involving human subjects must be pre-approved or exempted by an appropriate Institutional Review Board.